Comparative Study of Cryotherapy versus Trichloroacetic Acid Chemical Peels in the Treatment of Actinic Keratosis

Authors

DOI:

https://doi.org/10.25079/ukhjse.v3n1y2019.pp59-63

Keywords:

Actinic keratosis, Cryotherapy, Squamous cell carcinoma, Trichlororacetic acid

Abstract

Actinic keratosis is cutaneous neoplasm which is including of expansion of cytologically unusual epidermal keratinocytes that grow in response to prolonged exposure to ultraviolet radiation. Since some percentage of actinic keratosis will develop to non-melanoma skin cancers, their treatment is recommended. The study aimed to evaluate the clinical effectiveness of cryotherapy in comparison to topical 25% trichloroacetic acid chemical peels in the treatment of actinic keratosis. A comparative therapeutic study was conducted on forty four patients with actinic keratosis who attended Erbil dermatology teaching center in Erbil city of Kurdistan Region-Iraq. Patients were randomly allocated into two groups: cryotherapy treatment with liquid nitrogen every two weeks and trichloroacetic acid peels every two weeks and the response was controlled on follow up by taking photos. Patient’s age ranged from 40 to 80 years, they were analyzed for 24 weeks. Good response rate was seen in 72.8% of cryotherapy group and 40.9% of trichloroacetic acid group and this was statistically significant (p=0.02).  Cryotherapy was more effective than trichloroacetic acid in the treatment of actinic keratosis.

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Author Biographies

  • Hawar J. Sabir, Dermatology Teaching Center, College of Medicine, Hawler Medical University, Erbil, Kurdistan Region - F.R. Iraq

    Hawar J. Sabir: She got MBChB degree from Hawler Medical University; College of Medicine in 2010.She has five years experience in Dermatology. She participated in many dermatological workshops and international conferences of Dermatology. Now, she is second year trainee of high diploma student at Erbil Dermatology teaching center.

  • Intiha M. Ridha, Dermatology Teaching Center, College of Medicine, Hawler Medical University, Erbil, Kurdistan Region - F.R. Iraq

    Intiha M. Ridha: She got PhD in Dermatology in 1979 from Istanbul University. She has also experienced many training courses; cryotherapy course at England for 3 months, laser treatment at France and many others. She has published many researches. Has attended  most of the international Dermatological conferences and workshops also has carried out many scientific posts; head of Dermatology department at Hawler Medical University for 17 years, has  taken  charge of Dermatology department at ministry of health, head of Dermatology department at Erbil directorate of health.

References

Berlin, J. M. (2010). Current and emerging treatment strategies for the treatment of actinic keratosis. Clinical Cosmetic and Investigational Dermatology, 17(3), 119-126.

Duncan, K. O., Geisse, J. K. & Leffell, D. J. (2011). Epithelial precancerous lesion. In: Goldsmith, L. A., Katz, S. I., Gilchrest, B. A., Paller, A. S., Leffcll, D. J. & Wolf, K., (Eds). Fitzpatrick’s Dermatology in General Medicine. 8th ed. New York: Mac Graw-Hill. pp. 661-170.

Fitzpatrick, J. E. & Morelli, J. G. (2011). Dermatology Secrets Plus. 4th ed. Philadelphia, PA: Elsevier, Mosby.

Girish, G., Vishal, M. & Lear, J. L. (2016). Squamous cell carcinoma and its precursors. In: Christopher, G., Breathnuch, S. M. & Cox, N., (Eds). Rooks Text Book of Dermatology. 9th ed. Oxford: Wiley.

James, W. D., Burger, T. G. & Elston, D. M. (2016). Andrew’s Disease of the Skin: Clinical Dermatology.12th ed. Philadelphia, PA: Elsevier. p. 634.

Khunger, N. & Iadvl, T. F. (2008). Standard guidelines of care for chemical peels. Indian Journal of Dermatology, Venereology and Leprology, 74 Suppl 1, 5-12.

Kligman, A. M., Baker, T. J. & Gordon, H. L. (1985). Long-term histologic follow-up of phenol face peels. Plastic and Reconstructive Surgery, 75, 652-659.

Lugo-Janer, A., Lugo-Somolinos, A. & Sanchez, J. L. (2003). Comparison of trichloroacetic acid solution and cryosurgery in the treatment of solar lentigines. International Journal of Dermatology, 42(10), 829-831.

Monheit, G. D. & Kayal, J. D. (2003). Chemical peeling. In: Nouri, K. & Leal-Khouri, S., (Eds). Techniques of Dermatologic Surgery. St Louis: Elsevier. pp. 233-244.

Salasche, S. J. (2000). Epidemiology of actinic keratoses and squamous cell carcinoma. Journal of the American Academy of Dermatology, 42(1), 4-7.

Savant, S. S., (Eds). (2005). Superficial and medium depth chemical peeling. In: Textbook of Dermatosurgery and Cosmetology. 2nd ed. Mumbai: ASCAD. p. 177-195.

Thai, K. E., Fergin, P., Freeman, M., Vinciullo, C., Francis, D., Spelman, L., Murrell, D., Anderson, C., Weightman, W., Reid, C., Watson, A. & Foley, P. (2004). A prospective study of the use of cryosurgery for the treatment of actinic keratoses. International Journal of Dermatology, 43(9), 687-692.

The British Association of Dermatology. (2008). Cryotherapy. Patient Information Leaflet. Product. Available from: http://www.bad.org. uk/site/1192/Default.aspx. [Last accessed on 2018 Mar].

Uhlenhake, E. E. (2013). Optimal treatment of actinic keratoses. Clinical Interventions in Aging, 8, 29-35.

Vachiramon, V. & Thadanipon, K. (2011). Postinflammatory hypopigmentation. Clinical and Experimental Dermatology,
36(7), 708-714.

Zhang, N., Gong, K., Zhang, X., Yang, Y. & Na, Y. (2010). Extra mammary paget’s disease of scrotum-report of 25 cases and literature review. Urologic Oncology, 28(1), 28-33.

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Published

2019-06-30

Issue

Vol. 3 No. 1 (2019): ISSUE FOUR

Section

Research Articles

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How to Cite

Comparative Study of Cryotherapy versus Trichloroacetic Acid Chemical Peels in the Treatment of Actinic Keratosis. (2019). UKH Journal of Science and Engineering, 3(1), 59-63. https://doi.org/10.25079/ukhjse.v3n1y2019.pp59-63

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